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Multiple Sclerosis l: Introduction

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Mobility, walking and physical activity in persons with multiple sclerosis.

Christine G Kohn¹, Craig I Coleman, C Michael White

¹Department of Pharmacy Practice, University of Connecticut School of Pharmacy , Storrs, CT , USA.

Current Medical Research and Opinion

|May 8, 2014

Summary

Mobility and walking impairments significantly reduce physical activity in people with multiple sclerosis (PwMS). Even moderate impairment leads to substantially less exercise, highlighting the need for targeted interventions.

Keywords:

Exercise Mobility Motor activity Multiple sclerosis Physical activity Walking

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The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

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Published on: June 30, 2014

Area of Science:

Neurology
Rehabilitation Science
Exercise Physiology

Background:

Physical activity (PA) is crucial for managing multiple sclerosis (MS).
The impact of varying mobility and walking limitations on PA levels in people with MS (PwMS) remains unclear.
Understanding this relationship can inform interventions to maintain PA in PwMS.

Purpose of the Study:

To quantify the association between mobility and walking impairments and the level of physical activity performed by PwMS.
To determine how different severities of walking disability affect PA in individuals with MS.

Main Methods:

Over 3000 individuals from the North American Research Committee on Multiple Sclerosis (NARCOMS) registry were assessed.
Mobility and walking impairment were measured using the Patient Determined Disease Steps (PDDS) scale and the 12-Item Multiple Sclerosis Walking Scale (MSWS-12).
Physical activity levels were estimated using the Godin Leisure-Time Exercise Questionnaire, and analyzed with multivariable regression models.

Main Results:

Moderate and severe mobility impairment (PDDS scale) were linked to significantly fewer weekly exercise volume (MET minutes/week) and reduced odds of achieving recommended PA levels.
Higher scores on the MSWS-12, indicating greater walking impairment, were associated with decreased PA volume and lower odds of meeting PA guidelines.
Statistical significance (p < 0.05) was observed across all comparisons between impairment levels and PA outcomes.

Conclusions:

Mobility and walking impairments are demonstrably associated with lower levels of physical activity in people with multiple sclerosis.
These findings underscore the importance of addressing mobility and walking challenges to promote physical activity in PwMS.
Future research should consider objective measures and mitigate recall bias to further refine understanding.