Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.2K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.2K
Assessment of apical radial pulse01:25

Assessment of apical radial pulse

1.6K
Apical-Radial (A-R) Pulse Assessment
The A-R pulse assessment involves simultaneous evaluation of the apical and radial pulses. When the apical and radial pulse rates vary, this assessment helps identify a pulse deficit.
Pre-Procedural Preparation
1.6K
Archival Research01:40

Archival Research

15.6K
Some researchers gain access to large amounts of data without interacting with a single research participant. Instead, they use existing records to answer various research questions. This type of research approach is known as archival research. Archival research relies on looking at past records or data sets to look for interesting patterns or relationships. For example, a researcher might access the academic records of all individuals who enrolled in college within the past ten years and...
15.6K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Readability of sexual health educational materials: a comparative analysis of ISSM resources and large language model-generated content.

The journal of sexual medicine·2026
Same author

Correction: Penile prosthesis implantation: a systematic review of intraoperative and postoperative complications.

International journal of impotence research·2026
Same author

Development and validation of PEYRO-Q: a novel multidimensional patient-reported outcome measure for Peyronie's disease.

Sexual medicine·2026
Same author

Frail and forgotten: an EAU YAU call for trainee-led research on frailty in urology.

BJU international·2026
Same author

Are We Still Mediterranean? Dietary Quality and Adherence in Sicilian Women Undergoing ART: A Prospective Observational Cohort Study.

Medicina (Kaunas, Lithuania)·2026
Same author

Impact of Negative Prostate-specific Membrane Antigen Positron Emission Tomography on the Decision to Perform a Pelvic Lymph Node Dissection During Radical Prostatectomy for Intermediate- to High-risk Prostate Cancer Patients: Results of an International Survey.

European urology open science·2026

Related Experiment Video

Updated: Apr 30, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

26.6K

[5ARI and PSA: evidences].

Giuseppe Morgia1, Daniele Urzì, Giorgio Ivan Russo

  • 1Department of Urology, School of Medicine, Policlinico Hospital, University of Catania, Catania - Italy.

Urologia
|May 8, 2014
PubMed
Summary
This summary is machine-generated.

5alpha-reductase inhibitors (5ARIs) reduce prostate-specific antigen (PSA) levels during benign prostatic hyperplasia treatment. While improving PSA test specificity for prostate cancer (CaP), other clinical factors are crucial for accurate CaP diagnosis.

More Related Videos

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

19.4K
Retzius-Sparing Robot-Assisted Radical Prostatectomy
12:10

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

9.6K

Related Experiment Videos

Last Updated: Apr 30, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

26.6K
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

19.4K
Retzius-Sparing Robot-Assisted Radical Prostatectomy
12:10

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

9.6K

Area of Science:

  • Urology
  • Oncology
  • Pharmacology

Background:

  • 5alpha-reductase inhibitors (5ARIs) are used for long-term benign prostatic hyperplasia (BPH) management.
  • Interpreting prostate-specific antigen (PSA) level variations during 5ARI therapy is a key clinical challenge.

Purpose of the Study:

  • To analyze PSA level changes over time during 5ARI treatment.
  • To evaluate the sensitivity and specificity of PSA for prostate cancer (CaP) screening in patients on 5ARIs.

Main Methods:

  • Literature search of PubMed and Scopus databases.
  • Keywords included: 5ARI, finasteride, dutasteride, prostate cancer, BPH, PSA, kinetics, PSA derivatives.

Main Results:

  • PSA levels decrease up to 48 months during 5ARI therapy.
  • 5ARIs may enhance PSA test performance for CaP screening but can reduce indolent cancer diagnoses.
  • PSA increases from nadir warrant suspicion, but biopsy decisions require additional clinical data.

Conclusions:

  • 5ARIs improve PSA test specificity for CaP detection.
  • PSA monitoring alone is insufficient for identifying aggressive CaP; clinical factors are essential.