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Updated: Apr 30, 2026
05:16
Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
803
Copeptin decrease from admission to discharge has favorable prognostic value for 90-day events in patients admitted
Clinical Chemistry and Laboratory Medicine
|May 8, 2014
Summary
Copeptin levels at admission and discharge, and their changes, predict 90-day death and rehospitalization in patients with acute dyspnea. This biomarker aids risk stratification for emergency department patients.
Area of Science:
- Cardiology
- Emergency Medicine
- Biomarkers
Background:
- Acute dyspnea is a common emergency department presentation requiring risk stratification.
- Copeptin shows prognostic value for adverse events in dyspneic patients.
Purpose of the Study:
- To investigate the prognostic role of copeptin variations during hospitalization in patients admitted for acute dyspnea.
Main Methods:
- Prospective, multicentric, observational study of 336 acute dyspneic patients.
- Copeptin levels measured at admission and discharge.
- 90-day follow-up for death and rehospitalization.
Main Results:
- Elevated admission copeptin levels (median 31 pmol/L) compared to controls (median 8 pmol/L).
- Higher copeptin in acute heart failure patients (42 pmol/L) vs. others (20 pmol/L).
- Admission, discharge, and delta copeptin levels significantly predicted 90-day adverse events (p<0.001).
Conclusions:
- Copeptin variations at admission, discharge, and during hospitalization are significant predictors of 90-day mortality and rehospitalization.
- Copeptin aids risk assessment in acute dyspnea patients.
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