Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:19

Cell Migration

6.1K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.1K
Cell Migration01:09

Cell Migration

16.6K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
16.6K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

8.6K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.6K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

1.9K
1.9K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

6.4K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
6.4K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

1.5K
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early lineage segregation of primary myotubes from secondary myotubes and adult muscle stem cells.

Nature communications·2025
Same author

TEADlight, a bright dynamic reporter for live detection of YAP/TAZ-TEAD signaling.

Developmental biology·2025
Same author

Corrigendum to "Avian bioresources for developmental biology: Transgenic chicken and quail resources in the United Kingdom, France, and Japan" [Dev. Biol. 521 (2025) 1-13].

Developmental biology·2025
Same author

Avian bioresources for developmental biology: Chicken and quail resources in the United Kingdom, France, and Japan.

Developmental biology·2025
Same author

The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening.

Cell metabolism·2024
Same author

A Lifeact-EGFP quail for studying actin dynamics in vivo.

The Journal of cell biology·2024

Related Experiment Video

Updated: Apr 30, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

1.3K

Migrating cells mediate long-range WNT signaling.

Olivier Serralbo1, Christophe Marcelle

  • 1EMBL Australia, Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia.

Development (Cambridge, England)
|May 8, 2014
PubMed
Summary
This summary is machine-generated.

WNT proteins are delivered to somites by migrating neural crest cells, not secreted from the neural tube. This novel signaling mechanism, involving GPC4, is crucial for embryonic development and somite patterning.

Keywords:
Chick embryoDermomyotomeSomiteWNT

More Related Videos

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

10.2K
Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration
06:42

Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration

Published on: May 24, 2024

2.1K

Related Experiment Videos

Last Updated: Apr 30, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

1.3K
Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

10.2K
Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration
06:42

Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration

Published on: May 24, 2024

2.1K

Area of Science:

  • Developmental biology
  • Cell signaling
  • Embryology

Background:

  • WNT proteins secreted from the dorsal neural tube are thought to pattern somites via a concentration gradient.
  • The precise mechanism of WNT distribution during early embryonic development remains incompletely understood.

Purpose of the Study:

  • To investigate the mechanism of WNT protein delivery to somites in the chicken embryo.
  • To identify the role of neural crest cells and associated molecules in WNT signaling.

Main Methods:

  • Inhibition of neural crest cell migration.
  • Ablation of neural crest cell populations.
  • Analysis of WNT response in somites.
  • Investigating the role of GPC4 in WNT delivery.

Main Results:

  • WNT proteins are loaded onto migrating neural crest cells for delivery to somites.
  • Disrupting neural crest migration or presence significantly impacts WNT signaling in somites.
  • Heparan sulfate proteoglycan GPC4, expressed by neural crest, is essential for efficient WNT delivery.

Conclusions:

  • WNT proteins utilize migratory neural crest cells as a transport system to pattern distant somites.
  • This represents a novel mode of signaling in embryonic development, challenging the traditional view of WNT gradient formation.
  • Neural crest-mediated WNT delivery is critical for proper somite organization and myotome patterning.