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Related Experiment Videos

Tenascin distribution in basal cell carcinomas.

G W Stamp1

  • 1ICRF/RCS Histopathology Unit, London, U.K.

The Journal of Pathology
|November 1, 1989
PubMed
Summary

Tenascin, an extracellular matrix protein, shows varied distribution in basal cell carcinomas. Its presence is linked to tumor stroma, interactions, and regression, suggesting a role in skin neoplasms.

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Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Tenascin is an extracellular matrix protein involved in epithelial-mesenchymal interactions.
  • It is highly expressed in the stroma during morphogenesis and in malignant neoplasms.

Purpose of the Study:

  • To assess the distribution of tenascin in basal cell carcinomas.
  • To investigate the relationship between tenascin expression and tumor characteristics.

Main Methods:

  • Cryostat sections of 17 basal cell carcinomas were analyzed.
  • A polyclonal antibody was used for tenascin staining.

Main Results:

  • Marked tenascin staining was observed in the vascularized stroma around neoplastic islands.
  • Staining was intense and well-defined, becoming more diffuse in infiltrative areas.
  • Enhanced staining was noted in tumors with retraction artifact, and reduced staining in areas of regression.

Conclusions:

  • Tenascin is a significant component of the stroma in basal cell carcinomas.
  • Its distribution correlates with tumor morphology and potential regression.
  • Further research on tenascin in skin tumors is warranted.

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