Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.9K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.9K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

1.9K
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.9K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

805
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
805
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.8K
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

753
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
753
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

1.3K
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Monocytes of patients with unstable angina express high levels of chemokine and pattern-recognition receptors.

Cytokine·2018
Same author

Obesity and hypertension in Latin America: Current perspectives.

Hipertension y riesgo vascular·2018
Same author

Behavioural determinants of salt consumption among hypertensive individuals.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2012
Same author

CYBA C242T polymorphism is associated with obesity and diabetes mellitus in Brazilian hypertensive patients.

Diabetic medicine : a journal of the British Diabetic Association·2012
Same author

Mannose-binding lectin (MBL2) polymorphisms and inflammation in hypertensive patients.

International journal of immunogenetics·2011
Same author

Hip circumference is associated with high density lipoprotein cholesterol response following statin therapy in hypertensive subjects.

Journal of endocrinological investigation·2011

Related Experiment Video

Updated: Apr 30, 2026

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

4.6K

Myocardial remodeling in hypertension.

W Nadruz1

  • 1Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, Brazil.

Journal of Human Hypertension
|May 9, 2014
PubMed
Summary

Left ventricular hypertrophy in hypertension is complex, not always adaptive. This condition, characterized by changes in heart muscle structure, is linked to poor cardiovascular outcomes and may not be a simple response to high blood pressure.

Area of Science:

  • Cardiology
  • Physiology
  • Hypertension Research

Background:

  • Left ventricular (LV) hypertrophy and remodeling are common in hypertension, influenced by multiple factors beyond blood pressure.
  • Traditional views suggested LV hypertrophy is an adaptive response to hypertension, preventing heart failure.
  • Recent evidence challenges this, indicating LV hypertrophy may not be adaptive and is linked to adverse outcomes.

Purpose of the Study:

  • To review the current understanding of left ventricular (LV) hypertrophy in hypertension.
  • To challenge the traditional view of LV hypertrophy as a solely adaptive response.
  • To explore the complex factors influencing LV remodeling and its association with cardiovascular outcomes.

Main Methods:

  • Literature review and synthesis of existing research on hypertensive cardiovascular remodeling.

More Related Videos

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

6.1K
Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

27.4K

Related Experiment Videos

Last Updated: Apr 30, 2026

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

4.6K
A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

6.1K
Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

27.4K
  • Analysis of studies investigating LV geometric patterns and their clinical significance.
  • Examination of experimental evidence regarding cardiomyocyte hypertrophy and cardiac function.

    • Main Results:

    • Concentric hypertrophy is not the most frequent geometric pattern in hypertensive subjects; eccentric hypertrophy is more common.
    • The transition from LV hypertrophy to dilation and systolic dysfunction is less common than previously thought, especially without coronary heart disease.
    • LV hypertrophy is consistently associated with increased cardiovascular morbidity and mortality, questioning its adaptive role.

    Conclusions:

    • Left ventricular hypertrophy in hypertension is a complex phenotype, not necessarily an adaptive response.
    • Factors like ethnicity, gender, salt intake, obesity, diabetes, and genetics modulate LV remodeling.
    • The hypertrophic myocardium exhibits detrimental changes (fibrosis, apoptosis) predicting adverse cardiovascular outcomes.