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Updated: Apr 30, 2026

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
Published on: August 28, 2012
Amyloid triangles, squares, and loops of apolipoprotein C-III
Michel de Messieres1, Rick K Huang, Yi He
1Laboratory of Molecular Biophysics and ‡Protein Expression Facility, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, and §Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland 20892, United States.
Abstract:
While a significant component of atherosclerotic plaques has been characterized as amyloid, the specific proteins remain to be fully identified. Probable amyloidogenic proteins are apolipoproteins (Apos), which are vital for the formation and function of lipoproteins. ApoCIII is an abundant protein implicated in atherosclerosis, and we show it forms a ribbonlike looped amyloid, strikingly similar to that previously reported for ApoAI and ApoCII. Triangles and squares with a width of ~50 nm were also observed, which may be a novel form of amyloid or related to previously reported amyloid rings.
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