Fast imine equilibration and its consequences for the evaluation of dynamic combinatorial libraries
K Ziach1, A Kulesza, J Jurczak
1Faculty of Chemistry, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland.
Organic & Biomolecular Chemistry
|May 9, 2014
Abstract:
An example of the subtle interplay between the intended templation and a very fast reequilibration of a dynamic combinatorial library of imines that occurs upon a solvent change is reported. Such seemingly "irrelevant" details of the procedure like imine dissolution time prior to reduction may dictate the outcome of the whole reaction.
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