Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

160
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
160
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.2K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extracellular vesicle-mediated HIF-1α delivery promotes durable vascular remodeling via endothelial Dll1-dependent CD163<sup>+</sup> macrophage differentiation.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Therapeutic reprogramming of circulating myeloid cells via signal regulatory protein α extracellular vesicles in acute kidney injury.

Kidney international·2025
Same author

Doppel as an early-stage biomarker promoting EMT and dissemination in ovarian cancers.

International journal of cancer·2025
Same author

Breaking barriers: Engineering extracellular vesicles for enhanced endosomal escape and therapeutic delivery.

Journal of controlled release : official journal of the Controlled Release Society·2025
Same author

TGFBI Facilitates Myogenesis and Limits Fibrosis in Mouse Skeletal Muscle Regeneration.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Apr 30, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.0K

Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy.

Ran Namgung1, Yeong Mi Lee1, Jihoon Kim1

  • 11] Center for Self-assembly and Complexity, Institute for Basic Science, Pohang 790-784, Korea [2] Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.

Nature Communications
|May 9, 2014
PubMed
Summary

A novel nano-assembled drug delivery system using polymer-cyclodextrin and polymer-paclitaxel conjugates shows high stability and efficient cancer cell targeting. This targeted paclitaxel delivery system demonstrates significant anticancer activity in preclinical models.

More Related Videos

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

10.2K
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

14.2K

Related Experiment Videos

Last Updated: Apr 30, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.0K
Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

10.2K
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

14.2K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmacology

Background:

  • Developing stable and effective targeted drug delivery systems is crucial for anticancer therapy.
  • Efficient drug uptake by tumor cells and stability during circulation are key challenges.

Purpose of the Study:

  • To create a novel nano-assembled drug delivery system with enhanced stability and targeted cancer cell uptake.
  • To evaluate the in vivo anticancer efficacy of the developed system.

Main Methods:

  • Nano-assembly formation via multivalent host-guest interactions between polymer-cyclodextrin and polymer-paclitaxel conjugates.
  • Utilizing passive and active targeting mechanisms for cancer cell delivery.
  • Assessing antitumour activity in a mouse tumour model.

Main Results:

  • The nano-assembly demonstrated high stability during circulation.
  • Efficient delivery of paclitaxel into targeted cancer cells was achieved.
  • Significant antitumour activity was observed in the mouse model.

Conclusions:

  • The novel targeted nano-assembly provides an effective strategy for anticancer drug delivery.
  • The host-guest interaction approach offers insights for developing advanced drug delivery systems.