Overweight, adipocytokines and hypertension: a prospective population-based study
Ekim Seven1, Lise L N Husemoen, Kristian Wachtell
1aCardiovascular Research Unit, Department of Internal Medicine bResearch Centre for Prevention and Health, Copenhagen University Hospital Glostrup, Glostrup cFaculty of Health Sciences, University of Copenhagen, Copenhagen dDepartment of Medicine, Copenhagen University Hospital Holbæk, Holbæk, Denmark.
Journal of Hypertension
|May 9, 2014
Summary
Leptin, a hormone from fat tissue, may link obesity to hypertension. Adiponectin and CRP did not show this link, but higher BMI strongly predicted hypertension, suggesting other factors are involved.
Area of Science:
- Endocrinology
- Cardiovascular Disease Research
- Metabolic Syndrome Studies
Background:
- Adipose tissue releases adipocytokines like leptin, adiponectin, and interleukin-6.
- These adipocytokines are implicated in stimulating C-reactive protein (CRP) production in the liver.
- They are considered potential mediators linking obesity to hypertension.
Purpose of the Study:
- To investigate the association between leptin, adiponectin, and CRP levels with prevalent and incident hypertension.
- To explore the role of these adipocytokines as potential intermediates in overweight-induced hypertension.
Main Methods:
- A population-based study of 5,868 Danish adults was conducted.
- Leptin, adiponectin, and CRP levels were measured.
- Associations with prevalent and 5-year incident hypertension were analyzed, adjusting for multiple confounders.
Main Results:
- Leptin was significantly associated with both prevalent and incident hypertension.
- C-reactive protein (CRP) was associated with prevalent hypertension but not incident hypertension.
- Adiponectin showed no significant association with either prevalent or incident hypertension.
- Higher Body Mass Index (BMI) was a strong independent predictor of incident hypertension, with a nearly two-fold increase in risk.
Conclusions:
- Leptin may play a mediating role in hypertension associated with being overweight.
- Adiponectin and CRP do not appear to mediate overweight-induced hypertension.
- While leptin is implicated, other factors are crucial in the pathogenesis of hypertension related to excess weight, as indicated by the strong independent effect of BMI.
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