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Alpha-bulges in G protein-coupled receptors

Rob van der Kant1, Gert Vriend2

  • 1Centre for Molecular and Biomolecular Informatics, Radboud University Medical Centre, Geert Grooteplein 26-28, 6525 GA Nijmegen, The Netherlands. Rob.vanderKant@switch.vib-kuleuven.be.

International Journal of Molecular Sciences
|May 9, 2014
PubMed
Summary

Alpha-bulges in G protein-coupled receptors (GPCRs) are crucial for ligand binding and activation. These structural elements facilitate G protein binding by enabling key helix movements during receptor activation.

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