Effect of Z-103 on compound 48/80-induced gastric lesions in rats

Z-103 (a novel anti-ulcer agent), given p.o. at doses of 30 and 100 mg/kg, significantly prevented gastric lesions induced by compound 48/80 in rats. Z-103 inhibited the histamine release from rat peritoneal mast cells stimulated by compound 48/80 in a dose-dependent manner. Z-103 inhibited the increase in thiobarbituric acid (TBA) reactants induced by a single or repeated administration of compound 48/80 in the gastric mucosa. These observations suggested that the protective effect of Z-103 against compound 48/80-induced gastric lesions may be due to its stabilizing activity toward mast cells and/or an antioxidative effect on the gastric mucosa.