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The measurement of gastric mucus using a computer image processing system.
M Kagoshima1, H Kodaira, Y Motoyoshi
1Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1989
Summary
A new computer image processing system effectively measured gastric mucus changes. Aspirin reduced mucus, while teprenone and secretin showed varying effects, highlighting the system's utility.
Area of Science:
- Gastroenterology and Pharmacology
- Biomedical Engineering and Imaging
Background:
- Gastric mucus plays a crucial role in protecting the stomach lining from damage.
- Quantifying gastric mucus components and their response to drugs is essential for understanding antiulcer mechanisms.
Purpose of the Study:
- To investigate the effects of aspirin and antiulcer drugs on gastric mucus content and composition.
- To evaluate a novel computer image processing system for measuring gastric mucus.
Main Methods:
- A computer image processing system was developed to quantify mucus components: PAS-positive (PAS+) and AB-positive (AB+).
- Normal rats were treated with aspirin, teprenone, secretin, cimetidine, and omeprazole.
- Changes in PAS+ and AB+ mucus levels were measured and compared with microscopic observations.
Main Results:
- Aspirin significantly decreased both PAS+ and AB+ mucus levels.
- Teprenone increased the total gastric mucus (PAS+ plus AB+).
- Secretin showed a tendency to increase AB+ mucus, while cimetidine and omeprazole had no significant effect on mucus secretion.
Conclusions:
- The developed computer image processing system is highly effective for measuring gastric mucus quantity and composition.
- Different drugs exert distinct effects on gastric mucus, providing insights into their antiulcer properties.
- This technology aids in the objective assessment of gastric mucosal protection.