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Updated: Apr 30, 2026
08:15
Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids
Published on: November 15, 2019
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Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation
James P Bridges1, Angelica Schehr1, Yanhua Wang1
1Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.
Plos One
|May 9, 2014
Summary
Sterol regulatory element-binding proteins (SREBP) are crucial for lung surfactant production. This study reveals SREBP signaling
Area of Science:
- Pulmonary biology
- Molecular genetics
- Lipid metabolism
Background:
- Pulmonary surfactant is vital for lung function, and its defects cause respiratory distress syndromes.
- Lipogenesis, regulated by SREBP signaling, is essential for surfactant synthesis in type II epithelial cells.
Purpose of the Study:
- To investigate the role of epithelial SREBP signaling in perinatal mouse lung maturation.
- To identify SREBP-regulated genes, pathways, and interactions during lung development.
Main Methods:
- Genome-wide mRNA expression profiling in transgenic mice with epithelial-specific Scap or Insig1/2 deletions.
- Functional enrichment analysis, pathway mapping, and literature mining.
Main Results:
- SREBP signaling impacts epithelial development, cell death, and proliferation at E17.5.
- Postnatally, SREBP primarily influences surfactant physiology, lipid synthesis, and phospholipid transport.
- SREBP signaling integrates with Wnt/β-catenin and glucocorticoid receptor pathways.
Conclusions:
- Epithelial SREBP signaling is a key regulator of perinatal lung lipogenesis and maturation.
- SREBP controls lung development and function through interactions with multiple regulatory partners.
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