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Complementary interactions between command-like interneurons that function to activate and specify motor programs.

Jin-Sheng Wu1, Nan Wang, Michael J Siniscalchi

  • 1Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York 10029, and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Jiangsu 210093, China.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|May 9, 2014
PubMed
Summary
This summary is machine-generated.

Two types of command-like neurons, cerebral-buccal interneuron-2 (CBI-2) and CBI-11, work together to control feeding motor programs in Aplysia. CBI-2 activates programs, while CBI-11 specifies ingestive actions, showing complementary roles in motor control.

Keywords:
Aplysiacentral pattern generatorcommand neuronselectrical couplingfeedingpopulation coding

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Area of Science:

  • Neuroscience
  • Motor Control
  • Computational Neuroscience

Background:

  • Motor activity is initiated by command-like interneurons.
  • Less reliable interneurons' roles in program generation are not well understood.
  • Cerebral-buccal interneuron-2 (CBI-2) activates feeding programs in Aplysia, containing FCAP and CP2 peptides.

Purpose of the Study:

  • Investigate the function of CBI-11, a less reliable command-like interneuron.
  • Determine how CBI-2 and CBI-11 interact to generate feeding motor programs.
  • Clarify the complementary roles of different command-like interneurons.

Main Methods:

  • Electrophysiological recordings in Aplysia californica.
  • Peptide content analysis of CBI-2 and CBI-11.
  • Stimulation experiments to assess program activation and specification.

Main Results:

  • CBI-11 contains FCAP but not CP2, and is a weaker program activator than CBI-2.
  • CBI-11 effectively specifies ingestive motor programs.
  • Prestimulation of CBI-2 enhances CBI-11's program-driving ability, partly via CP2.
  • Coactivation of CBI-11 with CBI-2 ensures immediate ingestive motor activity.

Conclusions:

  • CBI-2 and CBI-11 exhibit complementary functions in motor program generation.
  • Different classes of command-like neurons contribute distinctly as activators or specifiers.
  • This study elucidates the cooperative mechanisms underlying motor program control.