Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Somatosensation01:33

Somatosensation

36.9K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
36.9K
Responses to Gravity and Touch02:26

Responses to Gravity and Touch

35.0K
Gravitropism: Plant Responses to Gravity
35.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated multi-technology exploration of the mechanism by which Badushengji San regulates core targets in diabetic foot ulcer.

Molecular genetics and genomics : MGG·2026
Same author

Ultrasound-Guided Drug Injection Combined With Suprascapular Nerve Pulsed Radiofrequency for Post-Stroke Hemiplegic Shoulder Pain: A Randomized Controlled Trial.

American journal of physical medicine & rehabilitation·2026
Same author

Synaptic and neural pathway redundancy enables the robustness of a sensory-motor reflex and promotes predation escape in <i>Caenorhabditis elegans</i>.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

High-performance quarter-wave plate based on the effective graded impedance matching configuration at 220 GHz.

Optics express·2026
Same author

Topographic structure and function of locus coeruleus norepinephrine neurons.

bioRxiv : the preprint server for biology·2026
Same author

Photothermal-Mediated Carrier Dynamics in Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene Revealed by Time-Resolved Terahertz Spectroscopy.

Small (Weinheim an der Bergstrasse, Germany)·2026

Related Experiment Video

Updated: Apr 30, 2026

Using a Microfluidics Device for Mechanical Stimulation and High Resolution Imaging of C. elegans
10:39

Using a Microfluidics Device for Mechanical Stimulation and High Resolution Imaging of C. elegans

Published on: February 19, 2018

10.0K

Modulation of C. elegans touch sensitivity is integrated at multiple levels.

Xiaoyin Chen1, Martin Chalfie

  • 1Department of Biological Sciences, Columbia University, New York, New York 10027.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|May 9, 2014
PubMed
Summary

Sensory systems adapt touch sensitivity through integrated signals. Caenorhabditis elegans show that mechanical and non-mechanical cues converge to regulate touch receptor neurons (TRNs) via integrin and insulin pathways.

Keywords:
insulin signalingintegrin signalinglong-term sensitizationmechanosensationsensory modulation

More Related Videos

An Anoxia-starvation Model for Ischemia/Reperfusion in C. elegans
09:24

An Anoxia-starvation Model for Ischemia/Reperfusion in C. elegans

Published on: March 11, 2014

9.7K
A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay
06:45

A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay

Published on: July 26, 2017

6.3K

Related Experiment Videos

Last Updated: Apr 30, 2026

Using a Microfluidics Device for Mechanical Stimulation and High Resolution Imaging of C. elegans
10:39

Using a Microfluidics Device for Mechanical Stimulation and High Resolution Imaging of C. elegans

Published on: February 19, 2018

10.0K
An Anoxia-starvation Model for Ischemia/Reperfusion in C. elegans
09:24

An Anoxia-starvation Model for Ischemia/Reperfusion in C. elegans

Published on: March 11, 2014

9.7K
A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay
06:45

A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay

Published on: July 26, 2017

6.3K

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Genetics

Background:

  • Sensory systems exhibit adaptability to diverse environmental stimuli.
  • Understanding the integration of multiple signals in sensory adaptation is crucial.

Purpose of the Study:

  • To identify conditions modulating touch sensitivity in Caenorhabditis elegans.
  • To elucidate the molecular mechanisms and integration points of sensory modulation.

Main Methods:

  • Investigated touch sensitivity in Caenorhabditis elegans under various conditions (vibration, hypoxia, dauer, high salt).
  • Utilized genetic and molecular approaches to study integrin and insulin signaling pathways.
  • Examined the role of neuroregulators, AKT kinases, and DAF-16/FOXO in sensory integration.

Main Results:

  • Prolonged vibration sensitizes touch receptor neurons (TRNs) via integrin signaling.
  • Hypoxia, dauer state, and high salt reduce touch sensitivity by inhibiting neuroregulator release.
  • Integration occurs at neurohormonal cells and within TRNs, converging on AKT/DAF-16 pathways.

Conclusions:

  • Sensory modulation in C. elegans is integrated at multiple levels, producing a unified output.
  • Integrin and insulin pathways can compensate for each other, allowing adaptation to conflicting signals.
  • This system enables adaptation of touch sensitivity to both mechanical and non-mechanical environmental conditions.