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Related Experiment Video

Updated: Apr 30, 2026

In Vivo Two-photon Imaging Of Experience-dependent Molecular Changes In Cortical Neurons

In Vivo Two-photon Imaging Of Experience-dependent Molecular Changes In Cortical Neurons

Published on: January 5, 2013

Arc regulates experience-dependent persistent firing patterns in frontal cortex.

Ming Ren¹, Vania Cao, Yizhou Ye

¹Unit on Neural Circuits and Adaptive Behaviors, Genes Cognition and Psychosis Program, and Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|May 9, 2014

Summary

This summary is machine-generated.

Motor training enhances persistent firing in specific brain neurons by increasing the activity-regulated cytoskeleton-associated protein 1 (Arc). This gene-experience interaction regulates neural communication and memory.

Keywords:

Arc/Arg3.1 NMDA receptor experience dependent frontal cortex persistent activity

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Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Experience-dependent neural plasticity is crucial for learning and memory.
Studies often focus on synaptic changes, overlooking neuronal output patterns.
Mechanisms regulating experience-induced persistent firing in specific neuronal populations remain unclear.

Purpose of the Study:

To investigate the role of the activity-regulated Arc gene in experience-dependent persistent firing patterns.
To explore the molecular and cellular mechanisms linking gene expression to neuronal activity.
To understand how behavioral experience shapes neuronal communication.

Main Methods:

Utilized transgenic mice with Arc gene expression reporters.
Examined frontal cortical slices to analyze neuronal firing patterns.
Investigated Arc-deficient mice to assess the gene's necessity for persistent firing.

Main Results:

Motor training increased Arc expression in specific excitatory neurons.
Neurons with higher Arc expression exhibited persistent firing.
Arc deletion diminished experience-dependent persistent firing.
Persistent activity correlated with Arc-dependent NMDA receptor function.

Conclusions:

Arc plays a critical role in mediating experience-dependent persistent firing patterns.
Gene-experience interactions, via Arc, regulate neuronal communication.
Arc-dependent NMDA receptor function is key to emergent persistent activity.