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Prognostic and Predictive Biomarkers in Cancer
Meera Nair, Sardul Singh Sandhu, Anil K Sharma1
1Department of Biotechnology, M.M. University, Mullana (Ambala) Haryana-133207. anibiotech18@gmail.com.
Current Cancer Drug Targets
|May 9, 2014
Summary
Novel technologies are advancing cancer biomarker discovery for early detection and improved treatment. This review covers omics research, bioinformatics, and breast cancer biomarkers for better screening and patient management.
Area of Science:
- Biomarker Discovery
- Cancer Research
- Genomics
- Proteomics
- Metabolomics
Background:
- Cancer control benefits significantly from early detection of pre-invasive disease.
- Cancer involves genetic alterations in oncogenes, tumor suppressor genes, and DNA repair genes, offering biomarker development opportunities.
- Innovative technologies in genomics, proteomics, metabolomics, and imaging facilitate comprehensive cancer cell analysis.
Purpose of the Study:
- To review bioinformatics tools, databases, and software for cancer biomarker discovery.
- To summarize omics research strategies for developing cancer biomarkers.
- To discuss current and emerging breast cancer biomarkers and integrate omics data for improved cancer management.
Main Methods:
- Review of existing literature on bioinformatics tools and omics research strategies.
- Analysis of high-throughput biology reports for novel cancer signatures.
- Discussion of integrated omics data approaches for biomarker discovery.
Main Results:
- Omics approaches demonstrate potential in distinguishing cancer cells from normal cells and identifying cancer progression elements.
- Various omics strategies and bioinformatics tools aid in identifying novel cancer signatures.
- Current and emerging biomarkers for breast cancer detection are discussed.
Conclusions:
- Systematic integration of omics data accelerates cancer biomarker discovery.
- Improved cancer screening, prognosis, and therapeutic response management are anticipated.
- Advancements in biomarker discovery are crucial for effective cancer control and patient outcomes.
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