Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer

Area of Science:

• Molecular Biology
• Cancer Research
• Gene Regulation

Background:

• Serine/Arginine Splicing Factor 1 (SRSF1) is a key regulator in the SR protein family.
• SRSF1 influences numerous biological pathways, including mRNA metabolism and mRNA-independent processes.
• Its functions extend to miRNA processing, protein sumoylation, and nucleolar stress response.

Purpose of the Study:

• To review the structural features of SRSF1 in relation to splicing mechanisms and its diverse functions.
• To provide a list of alternatively spliced transcripts and SRSF1-interacting proteins.
• To emphasize the role of SRSF1 overexpression in cancer development and transformation.

Main Methods:

• Literature review and analysis of existing research on SRSF1.
• Discussion of SRSF1 structure-function relationships.
• Compilation of data on SRSF1 targets and interacting partners.

Main Results:

• SRSF1 possesses structural features enabling its multifaceted roles in splicing and other cellular activities.
• A comprehensive list of alternatively spliced transcripts and interacting proteins associated with SRSF1 is presented.
• Overexpression of SRSF1 as a proto-oncogene contributes to cancer pathogenesis through complex mechanisms.

Conclusions:

• SRSF1 plays an integral role in maintaining cellular homeostasis.
• Understanding SRSF1's functions provides insights into cancer biology.
• SRSF1 represents a potential therapeutic target for anticancer strategies.