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Lack of HPA-23 antiviral activity in HIV-infected patients without AIDS
M Burgard1, P Sansonetti, D Vittecoq
1Laboratoire de Microbiologie, Hôpital Necker, Paris, France.
AIDS (London, England)
|October 1, 1989
Abstract:
A randomized study of 12 treated patients and seven controls was conducted in order to evaluate HPA-23 anti-HIV activity in HIV-infected patients. The antiviral activity was assessed by determining HIV p24 antigenemia. A persistence or even increase in antigenemia was shown in treated patients and thrombocytopenia was observed in nine out of the 12 patients. This suggests that HPA-23 should not be used in anti-HIV therapy.