CO2 removal with hemodialysis and control of plasma oncotic pressure

CO2 removal by hemodialysis, associated with systemic alkalinization, is the simplest method of metabolic CO2 elimination. In this experimental work, the authors investigated the efficacy of this protocol in modifying an alkaline perfusate by addition of dextran 40. The results, unlike those of preceding experimental series without dextran, disclosed no significant change in weight, hemodynamic variables, electrolyte concentrations or osmotic or oncotic pressures after 12 hours. Sixty-five percent of metabolic CO2 was eliminated with a bypassed blood flow rate of only 8% of cardiac output.