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Characteristic sequences in the upstream region of the human tyrosinase gene
H Kikuchi1, H Miura, H Yamamoto
1Department of Cancer Chemotherapy and Prevention, Research Institute for Tuberculosis and Cancer, Sendai, Japan.
Biochimica Et Biophysica Acta
|December 22, 1989
Abstract:
A human tyrosinase gene containing a 5'-flanking region and the first exon was isolated from a normal human liver library using mouse tyrosinase cDNA as a probe for screening. In the 5'-upstream region of transcriptional start sites, there is a putative TATA box and CAAT box and some palindromic sequences. A characteristic sequence of (GA:TCn, which can assume a hinged-DNA structure, was present from -869 nt to -633 nt in this 5'-flanking region.