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Towards the prevention of neural tube defects
1Human Genetics Unit, University of Edinburgh, Western General Hospital, UK.
Clinical Genetics
|November 1, 1989
Abstract:
The value of maternal periconceptional vitamin supplementation in preventing the conception of fetuses with neural tube defects has yet to be assessed in a properly designed study. Avoidance of the birth of affected infants continues to rest on second-trimester maternal serum alphafetoprotein screening. The performance of screening programmes in achieving this objective is reviewed.