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Efficient tissue-specific expression of bovine alpha-lactalbumin in transgenic mice
J L Vilotte1, S Soulier, M G Stinnakre
1Laboratoire de Génétique Biochimique, Institut National de la Recherche Agronomique, Jouy-en-Josas, France.
European Journal of Biochemistry
|December 8, 1989
Abstract:
Transgenic mice carrying a 3.2-kb genomic fragment comprising the bovine alpha-lactalbumin gene transcription unit with 750 bp and 336 bp of 5' and 3' flanking regions, respectively, were generated. Tissue-specific expression of the transgene was observed in five out of the six lines analyzed at levels close to the endogenous gene in two of them.