Related Experiment Video

Updated: Apr 30, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

4.5K

Invasive fungal infections in solid organ transplant recipients

J Gavaldà1, Y Meije, J Fortún

  • 1Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|May 10, 2014
PubMed

Insights

Solid organ transplant recipients face high risks of invasive fungal diseases (IFD), primarily from Candida and Aspergillus species. Definitive IFD guidelines are lacking, necessitating reliance on clinical experience for management.

Area of Science:

  • Medical Mycology
  • Transplant Infectious Diseases

Background:

  • Solid organ transplant (SOT) recipients are a vulnerable population.
  • Invasive fungal diseases (IFD) pose a significant threat to SOT recipients.

Purpose of the Study:

  • To highlight the epidemiology and challenges in managing IFD in SOT recipients.
  • To underscore the need for evidence-based guidelines for IFD in SOT.

Main Methods:

  • Review of current literature and clinical practices regarding IFD in SOT.
  • Analysis of common fungal pathogens, including Candida spp. and Aspergillus spp.

Main Results:

  • Candida spp. are the most common cause of IFD in SOT recipients.
  • Significant epidemiological variations exist across different transplant programs.
  • Lack of robust clinical trials limits definitive treatment and prevention recommendations.

Conclusions:

  • IFD management in SOT recipients currently relies heavily on clinical expertise.
  • Further research and clinical trials are crucial for developing standardized IFD protocols.
Keywords:
Drug interactionsTransplant infectious diseaseinvasive aspergillosisinvasive candidiasissolid organ transplantation

More Related Videos

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

17.8K
Murine Full-thickness Skin Transplantation07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

20.0K

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.4K
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
119
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
926
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
631
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
827
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
3.0K