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Related Concept Videos

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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First trimester screening can predict adverse pregnancy outcomes.

Andrew N Sharp1, Zarko Alfirevic

  • 1Department of Women and Children's Health Research, University Department, Liverpool Women's Hospital, Liverpool, UK.

Prenatal Diagnosis
|May 10, 2014
PubMed
Summary

Effective first trimester tests can identify women at risk for preeclampsia, fetal growth restriction, preterm birth, and gestational diabetes. However, reliable first-trimester stillbirth detection remains unavailable.

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Area of Science:

  • Maternal-fetal medicine
  • Obstetrics
  • Perinatology

Background:

  • Increasing focus on early detection of adverse pregnancy outcomes in the first trimester.
  • Numerous techniques and biomarkers exist, but clinical applicability is challenging.
  • Early diagnosis does not always guarantee improved maternal and child outcomes.

Purpose of the Study:

  • To evaluate the availability and clinical utility of first-trimester tests for predicting adverse pregnancy outcomes.
  • To identify specific conditions with effective first-trimester screening methods.

Main Methods:

  • Review of existing literature on first-trimester risk assessment for pregnancy complications.
  • Analysis of the effectiveness of current diagnostic techniques and biomarkers.
  • Assessment of clinical practicability and impact on maternal-child health.

Main Results:

  • Effective first-trimester tests are available for preeclampsia, fetal growth restriction, spontaneous preterm birth, and gestational diabetes.
  • No reliable first-trimester tests currently exist for identifying women at risk of stillbirth.
  • The field is dynamic, with ongoing development of new strategies.

Conclusions:

  • First-trimester screening is valuable for several key pregnancy complications.
  • Further research is needed to develop reliable stillbirth prediction in early pregnancy.
  • Continued advancements are expected to improve the management of high-risk pregnancies.