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Related Experiment Video

Updated: Apr 30, 2026

High-definition Transcranial Direct Current Stimulation over Right Dorsolateral Prefrontal Cortex to Enhance Metacognitive Sensitivity
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Metacognitive therapy versus cognitive behavioural therapy for depression: a randomized pilot study.

Jennifer Jordan1, Janet D Carter2, Virginia V W McIntosh3

  • 1Department of Psychological Medicine, University of Otago, Christchurch, New Zealand Clinical Research Unit, Canterbury District Health Board, Christchurch, New Zealand jenny.jordan@otago.ac.nz.

The Australian and New Zealand Journal of Psychiatry
|May 10, 2014
PubMed
Summary

Metacognitive therapy (MCT) and cognitive behavioural therapy (CBT) effectively treated depression in outpatients. This pilot study found similar outcomes for both depression treatments, though further research is needed.

Keywords:
Cognitive behavioural therapydepressionmetacognitiverandomized pilot study

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Area of Science:

  • Psychiatry
  • Clinical Psychology

Background:

  • Metacognitive therapy (MCT) is a novel approach within cognitive therapy.
  • Cognitive behavioural therapy (CBT) is an established treatment for depression.

Purpose of the Study:

  • To compare the efficacy and speed of independently applied MCT versus CBT in outpatients with depression.
  • To inform a planned larger randomized controlled trial.

Main Methods:

  • A randomized controlled pilot study involving 48 outpatients with depression.
  • Participants were randomized to up to 12 weeks of either MCT or CBT.
  • Depressive symptoms were assessed at weeks 4 and 12 using the Quick Inventory of Depressive Symptomatology (QIDS-16).

Main Results:

  • Both MCT and CBT demonstrated clinically significant reductions in depressive symptoms.
  • Moderate-to-large effect sizes were observed for both therapies.
  • No significant differences in overall or early treatment outcomes were found between MCT and CBT.

Conclusions:

  • MCT is an effective treatment for depression, yielding results comparable to CBT in this pilot study.
  • Comorbidity may have impacted MCT's efficacy, warranting further investigation.
  • Larger studies are required to definitively establish the comparative efficacy of MCT and CBT due to limitations in statistical power and comorbidity imbalance.