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Continuous positive airway pressure is associated with a decrease in pulmonary artery pressure in patients with

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  • 1Department of Pulmonary Medicine, Peking Union Medical College Hospital, Beijing, China.

Respirology (Carlton, Vic.)
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Summary

Continuous positive airway pressure (CPAP) significantly reduces pulmonary artery pressure in patients with obstructive sleep apnea (OSA). This finding suggests CPAP is a valuable treatment for OSA-related pulmonary hypertension.

Keywords:
continuous positive airway pressureobstructive sleep apnoeapulmonary artery hypertensionpulmonary hypertension

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Area of Science:

  • Cardiology
  • Pulmonology
  • Sleep Medicine

Background:

  • Obstructive sleep apnea (OSA) is linked to pulmonary hypertension.
  • Continuous positive airway pressure (CPAP) may lower pulmonary artery pressure in OSA patients, but evidence is limited.

Purpose of the Study:

  • To assess if CPAP treatment decreases pulmonary artery pressure in patients diagnosed with OSA.

Main Methods:

  • A systematic review and meta-analysis adhering to MOOSE guidelines.
  • Searched MEDLINE, EMBASE, and Cochrane Library up to May 2013 for relevant studies.
  • Included six articles (181 patients) comprising five before-after studies and one matched-control study.

Main Results:

  • CPAP treatment was associated with a statistically significant reduction in pulmonary artery pressure among OSA patients.
  • The standardized mean difference was -1.34 (95% CI: -2.33 to -0.34, P = 0.009).

Conclusions:

  • This meta-analysis indicates that CPAP is linked to decreased pulmonary artery pressure in individuals with OSA.
  • Despite limitations, the findings support CPAP's role in managing pulmonary hypertension in OSA.