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Updated: Apr 30, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Mantle cell lymphoma and systemic sclerosis
Abstract:
Systemic sclerosis (SSc) is a rare disease with an increased incidence of cancer, but the ocorrence of Non-Hodgkin lymphoma (NHL) is a very uncommon event. We report a case of a 76-year-old female addmited to the hematology clinic with long-term adenopathies and ocasional gastro-intestinal symptomatology. Progressive symmetrical swelling of hands was also noticed. Colonoscopy revealed multiple polyps and histopathology was consistent with Mantle-Cell Lymphoma (MCL)-NHL. R-CHOP (rituximab, cyclophosphamide, doxorubicine, vincristine and prednisone) regimen was promptly iniated with complete response. Persistent swelling of both hands was observed, with thickening of the skin of both hands with proximal extension until the forearm. Biopsy confirmed the diagnosis of scleroderma. Symptomatic and rehabilitation treatment was initiated with mild improvement of symptoms. To our knowledge this is the first case of MCL associated with SSc.
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