Related Experiment Video
Updated: Apr 30, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
Published on: January 12, 2018
The clinical relevance and newsworthiness of NIHR HTA-funded research: a cohort study
1National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre (NETSCC), University of Southampton, Southampton, Hampshire, UK.
Insights
The UK National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme successfully funds research with high clinical relevance. Their reports demonstrate significant value for healthcare investment and practice.
Area of Science:
- Health Technology Assessment
- Medical Research Funding
- Clinical Relevance Evaluation
Background:
- Assessing the impact of research funding is crucial for maximizing return on investment.
- The UK National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme funds research to inform healthcare decisions.
- Evaluating the clinical relevance and newsworthiness of funded research ensures its practical application.
Purpose of the Study:
- To evaluate the clinical relevance and newsworthiness of reports funded by the NIHR HTA Programme.
- To compare the quality of NIHR HTA publications with non-NIHR HTA publications.
- To determine if NIHR HTA funding effectively supports research impactful for clinical practice.
Main Methods:
- A retrospective cohort study analyzed 311 NIHR HTA Programme funded reports published between 2007 and 2012.
- The McMaster Online Rating of Evidence (MORE) system, utilizing over 4000 physicians, assessed clinical relevance and newsworthiness.
- Ratings were compared between NIHR HTA reports, non-NIHR HTA publications, and publications from the same studies appearing outside HTA.
Main Results:
- 92.0% of NIHR HTA reports were assessed, with 67.1% meeting MORE inclusion criteria.
- NIHR HTA reports showed statistically higher average clinical relevance (5.48) compared to non-NIHR HTA publications (5.32; p=0.01).
- Average newsworthiness ratings were similar between NIHR HTA and non-NIHR HTA publications (4.75 vs. 4.70; p=0.402), though original research reports were more newsworthy than reviews (p=0.001).
Conclusions:
- The NIHR HTA Programme effectively funds research that is clinically relevant.
- The findings support the value of investing in research that directly impacts clinical practice.
- The program demonstrates success in generating high-value research outputs for healthcare.
Objective:
To assess the clinical relevance and newsworthiness of the UK National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme funded reports.
Study Design:
Retrospective cohort study.
Setting:
The cohort included 311 NIHR HTA Programme funded reports publishing in HTA in the period 1 January 2007-31 December 2012. The McMaster Online Rating of Evidence (MORE) system independently identified the clinical relevance and newsworthiness of NIHR HTA publications and non-NIHR HTA publications. The MORE system involves over 4000 physicians rating publications on a scale of relevance (the extent to which articles are relevant to practice) and a scale of newsworthiness (the extent to which articles contain news or something clinicians are unlikely to know).
Main Outcome Measures:
The proportion of reports published in HTA meeting MORE inclusion criteria and mean average relevance and newsworthiness ratings were calculated and compared with publications from the same studies publishing outside HTA and non-NIHR HTA funded publications.
Results:
286/311 (92.0%) of NIHR HTA reports were assessed by MORE, of which 192 (67.1%) passed MORE criteria. The average clinical relevance rating for NIHR HTA reports was 5.48, statistically higher than the 5.32 rating for non-NIHR HTA publications (mean difference=0.16, 95% CI 0.04 to 0.29, p=0.01). Average newsworthiness ratings were similar between NIHR HTA reports and non-NIHR HTA publications (4.75 and 4.70, respectively; mean difference=0.05, 95% CI -0.18 to 0.07, p=0.402). NIHR HTA-funded original research reports were statistically higher for newsworthiness than reviews (5.05 compared with 4.64) (mean difference=0.41, 95% CI 0.18 to 0.64, p=0.001).
Conclusions:
Funding research of clinical relevance is important in maximising the value of research investment. The NIHR HTA Programme is successful in funding projects that generate outputs of clinical relevance.
More Related Videos
07:31Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
Published on: May 15, 2020
09:33Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
Published on: December 23, 2022
Related Concept Videos
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Clinical Trials: Overview
Clinical Trials
There are four phases in a clinical trial. A phase one...
Bioavailability Study Design: Healthy Subjects Versus Patients
Case Studies
Bias in Epidemiological Studies