Related Experiment Videos
Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel
U B Kaupp1, T Niidome, T Tanabe
1Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan.
Nature
|December 14, 1989
Abstract:
The complete amino-acid sequence of the cyclic GMP-gated channel from bovine retinal rod photoreceptors, deduced by cloning and sequencing its complementary DNA, shows that the protein contains several putative transmembrane segments, followed by a region that is similar to the cyclic GMP-binding domains of cyclic GMP-dependent protein kinase. Expression of the complementary DNA produces cyclic GMP-gated channel activity in Xenopus oocytes.