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The 24-hour pulse wave velocity, aortic augmentation index, and central blood pressure in normotensive volunteers
Tatyana Y Kuznetsova1, Viktoria A Korneva1, Evgeniya N Bryantseva2
1Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, Russia.
Insights
This study analyzed 24-hour pulse wave velocity and central blood pressure in 467 normotensive adults. Findings reveal circadian rhythms and sex differences in these cardiovascular indicators.
Area of Science:
- Cardiovascular Physiology
- Biomedical Engineering
Background:
- Ambulatory blood pressure monitoring (ABPM) is crucial for assessing cardiovascular health.
- Understanding central blood pressure and arterial stiffness provides deeper insights than peripheral measurements.
Purpose of the Study:
- To evaluate 24-hour pulse wave velocity (PWV), aortic augmentation index corrected for heart rate 75 (AIx@75), and central blood pressure in normotensive adults.
- To identify circadian variations and sex-based differences in these hemodynamic parameters.
Main Methods:
- Recruited 467 normotensive volunteers (206 men, 261 women), excluding those with specific health conditions.
- Utilized the BPLab device for 24-hour ambulatory blood pressure monitoring.
- Applied the Vasotens algorithm to analyze ABPM waveforms for calculating PWV, AIx@75, and central systolic/diastolic blood pressure during awake and asleep periods.
Main Results:
- Identified significant circadian rhythms in pulse wave velocity and central blood pressure.
- Observed distinct sex differences in aortic augmentation index and central blood pressure patterns.
- Established preliminary reference values for these indices derived from ABPM data.
Conclusions:
- Circadian variations and sex differences are significant factors in central hemodynamic parameters.
- The Vasotens algorithm provides valuable data for assessing arterial stiffness and central blood pressure via ABPM.
- These findings may serve as preliminary diagnostic values for enhanced ABPM analysis in adults, pending further validation.
Abstract:
The purpose of this study was to examine the pulse wave velocity, aortic augmentation index corrected for heart rate 75 (AIx@75), and central systolic and diastolic blood pressure during 24-hour monitoring in normotensive volunteers. Overall, 467 subjects (206 men and 261 women) were recruited in this study. Participants were excluded from the study if they were less than 19 years of age, had blood test abnormalities, had a body mass index greater than 2 7.5 kg/m(2), had impaired glucose tolerance, or had hypotension or hypertension. Ambulatory blood pressure monitoring (ABPM) with the BPLab(®) device was performed in each subject. ABPM waveforms were analyzed using the special automatic Vasotens(®) algorithm, which allows the calculation of pulse wave velocity, AIx@75, central systolic and diastolic blood pressure for "24-hour", "awake", and "asleep" periods. Circadian rhythms and sex differences in these indexes were identified. Pending further validation in prospective outcome-based studies, our data may be used as preliminary diagnostic values for the BPLab ABPM additional index in adult subjects.
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