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[Treatment of cerebral palsy children by integrative medical sequential method: a clinical efficacy observation]
Insights
Integrative medical sequential methods significantly improved intelligence and reduced muscle tension in children with cerebral palsy (CP). This approach also effectively lowered inflammatory markers, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).
Area of Science:
- Neurology
- Immunology
- Integrative Medicine
Context:
- Cerebral palsy (CP) presents significant challenges in children's development.
- Inflammatory markers like IL-6 and TNF-alpha are implicated in CP's pathophysiology.
- Optimizing treatment for CP requires exploring novel therapeutic strategies.
Purpose:
- To evaluate the efficacy of an integrative medical sequential method for treating cerebral palsy (CP).
- To assess the impact on children's intelligence development, muscular tension, and key inflammatory markers (IL-6, TNF-alpha).
Summary:
- 111 CP children received standard rehabilitation plus either standard treatment or an enhanced regimen including Chinese medical enema.
- The integrative group showed greater improvements in intelligence (Gesell scores) and reduced muscle tension.
- Significant reductions in serum IL-6 and TNF-alpha were observed in both groups, with a more pronounced effect in the integrative group.
Impact:
- The integrative approach demonstrated superior efficacy compared to standard treatment for CP.
- This suggests a synergistic effect of combining conventional and traditional Chinese medicine for CP management.
- Findings support optimizing CP treatment programs with integrative medical sequential methods.
Objective:
To observe the efficacy of integrative medical sequential method in treating cerebral palsy (CP) children's intelligence development, muscular tension, serum interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha).
Methods:
Totally 111 CP children were randomly assigned to the control group (50 cases) and the treatment group (61 cases). All patients received comprehensive rehabilitation training and intravenous dripping of Monosialotetrahexosylganglioside Sodium Injection for 10 days. But those in the treatment group additionally received Chinese medical enema for brain resuscitation, relieving rigidity of muscles and activating collaterals for 14 days. Then they started another medication cycle and lasted for a total of 6 cycles. Serum IL-6 levels and TNF-alpha contents were determined before treatment. Scoring for muscular tension, Gesell score for intelligence development, contents of serum IL-6 and TNF-alpha were assessed before and after treatment in the two groups.
Results:
Compared with before treatment in this group, muscular tension, Gesell scores for intelligence development all decreased in the two groups (P < 0.05). As for inter-group comparison, the decrement was more obvious in the treatment group than in the control group (P < 0.05). The total effective rate was 86.9% in the treatment group and 76.0% in the control group (P < 0.05). The contents of IL-6 and TNF-alpha were obviously reduced in the treatment group and the control group after treatment (P < 0.01). The decrement was more obvious in the treatment group (P < 0.05).
Conclusion:
The two treatment methods were effective for CP children, but the efficacy was superior in the treatment group than in the control group, indicating integrative medical methods could play a synergistic effect and optimize the treatment program for CP.
