Related Experiment Video

Updated: Apr 30, 2026

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
15:10

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

Published on: December 28, 2013

6.5K

Reliability of semiquantitative ¹⁸F-FDG PET parameters derived from simultaneous brain PET/MRI: a feasibility study

Amarnath Jena1, Sangeeta Taneja1, Reema Goel1

  • 1Department of Molecular Imaging and Nuclear Medicine, Indraprastha Apollo Hospitals, Sarita Vihar, Mathura Road, New Delhi 110076, Delhi, India.

European Journal of Radiology
|May 13, 2014
PubMed
Abstract

Insights

Simultaneous brain PET/MRI using ultrashort echo time (UTE) sequences for attenuation correction (AC) provides reliable quantitative accuracy comparable to PET/CT. This method ensures precise brain PET data quantitation in clinical settings.

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Radiology

Background:

  • Simultaneous brain PET/MRI requires accurate MRI-based attenuation correction (AC) for precise quantitation.
  • Unlike PET/CT, PET/MRI lacks standardized, validated AC methods, posing a challenge for quantitative analysis.

Purpose of the Study:

  • To evaluate the feasibility of semiquantitative (18)F-FDG PET parameters from simultaneous brain PET/MRI using ultrashort echo time (UTE) sequences for AC.
  • To assess the agreement of these parameters with those obtained from conventional PET/CT examinations.

Main Methods:

  • Sixteen patients underwent simultaneous brain PET/MRI and PET/CT scans.
  • Quantitative analysis of PET images was performed using Scenium v.1 software.
  • Six semiquantitative parameters (SUV max, SUV mean, SUV min, SD min, SD max, SD from mean) were calculated for 20 brain regions.
  • Intra-class correlation coefficients (ICCs) were used to assess agreement between PET/MRI and PET/CT data.

Main Results:

  • High intra-class correlation (ICC > 0.9) was observed between PET/MRI and PET/CT for SUV max, SUV mean, and SD max across all 20 brain regions (p<0.00).
  • Statistically significant agreement (ICC > 0.8) was also found for SD from mean.
  • However, PET/MRI yielded significantly lower SUV max and SUV mean values compared to PET/CT for all analyzed brain regions.

Conclusions:

  • MRI-based UTE sequences for AC in simultaneous brain PET/MRI are reliable for PET quantitation in clinical practice.
  • The quantitative accuracy achieved with this PET/MRI method is comparable to that of PET/CT.
  • This validates UTE-based AC as a viable approach for precise brain PET imaging with PET/MRI systems.
Keywords:
(18)F-FDG brain PET/CTAttenuation correctionPET quantitationSimultaneous brain PET/MRIUltrashort echo time sequence

More Related Videos

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury09:58

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

Published on: November 9, 2018

6.5K
Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

9.8K

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.2K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
853