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Updated: Apr 30, 2026

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells
Published on: January 25, 2020
Unraveling architecture of the pluripotent genome
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19103, USA.
Abstract:
Genomes are folded into sophisticated configurations that both shape, and are shaped by, a diverse range of nuclear functions. High-throughput variations of Chromosome-Conformation-Capture-based technologies now enable analysis of architecture at unprecedented resolution and scale. Here I discuss the complex structure-function relationship of the mammalian genome using the model system of embryonic stem cells, and the progression from pluripotency to terminal differentiation and back again.
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