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The provisional normal MSAFP screen.

P Meier, J Cole, S Wagner

Wisconsin Medical Journal

|November 1, 1989

Summary

This summary is machine-generated.

A normal maternal serum alpha-fetoprotein (MSAFP) screening does not rule out chromosomal abnormalities. This study reports a protocol to further evaluate potentially normal MSAFP results, preserving reproductive options for patients.

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Area of Science:

Maternal-fetal medicine
Prenatal diagnostics
Genetics

Background:

A provisional normal maternal serum alpha-fetoprotein (MSAFP) screening may still indicate a risk for chromosomal abnormalities.
Failure to identify this risk can limit reproductive choices for expectant parents.

Purpose of the Study:

To report a protocol for evaluating provisional normal MSAFP screening results.
To ensure patients are aware of and can act upon potential risks of chromosomal abnormalities.

Main Methods:

Retrospective review of patient data over an 18-month period.
Development and implementation of a standardized protocol for follow-up of "normal" MSAFP results.
Analysis of outcomes for patients undergoing the evaluation protocol.

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Main Results:

Patients with a provisional normal MSAFP screen are at significant risk for fetal chromosomal abnormalities.
The developed protocol aids in identifying these at-risk pregnancies.
Timely evaluation preserves reproductive options.

Conclusions:

A provisional normal MSAFP screen requires further investigation to rule out chromosomal abnormalities.
Implementing a structured evaluation protocol is crucial for comprehensive prenatal care.
Early identification of risk empowers patients with informed reproductive decisions.