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Chronic idiopathic axonal polyneuropathy and vitamin B6: a controlled population-based study
Nora A Visser1, Nicolette C Notermans, Lieveke A R Degen
1Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Journal of the Peripheral Nervous System : JPNS
|May 13, 2014
Summary
This study found no link between elevated vitamin B6 levels and chronic idiopathic axonal polyneuropathy (CIAP). While more CIAP patients used vitamin B6 supplements, their blood levels were not higher than controls.
Area of Science:
- Neurology
- Toxicology
- Nutritional Science
Background:
- Vitamin B6 intoxication is known to cause sensory ataxic neuropathy.
- The relationship between vitamin B6 and chronic idiopathic axonal polyneuropathy (CIAP) is not well understood.
- CIAP presents as a milder sensory or sensorimotor polyneuropathy.
Purpose of the Study:
- To investigate the association between vitamin B6 exposure and CIAP.
- To compare vitamin B6 levels and supplement use in CIAP patients versus healthy controls.
- To assess the impact of vitamin B6 supplement cessation on CIAP symptoms.
Main Methods:
- Prospective case-control study including 381 CIAP patients and 140 healthy controls.
- Standardized comparison of vitamin B6 supplement use and blood levels between groups.
- Follow-up assessment of patients after cessation of vitamin B6 supplements.
Main Results:
- Vitamin B6 levels were not significantly different between CIAP patients and controls.
- Patients with CIAP were more likely to use vitamin B6 containing supplements (31% vs 22%).
- Following supplement cessation, CIAP symptoms showed slow progression (64%), stabilization (26%), or regression (10%).
Conclusions:
- An association between CIAP and elevated vitamin B6 levels is unlikely.
- While supplement use was higher in CIAP patients, blood levels did not confirm toxicity.
- Further research may be needed, but current evidence does not support a strong link.
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