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B1 cells are unaffected by immune modulatory treatment in remitting-relapsing multiple sclerosis patients

Damiano Rovituso1, Stefanie Heller2, Michael Schroeter3

  • 1Department of Anatomy I, University Hospitals of Cologne, Joseph-Stelzman-Straße, 50931 Cologne, Germany; Department of Anatomy and Cell Biology, University of Wuerzburg, Koellikerstraße 6, 97070 Wuerzburg, Germany.

Journal of Neuroimmunology
|May 13, 2014
PubMed

In this study we aimed to investigate whether treatment with an immune modulatory drug had an effect on the distribution of B cell subpopulations in patients with remitting-relapsing multiple sclerosis (RRMS). We investigated the first-line drugs glatiramer acetate, interferon-β and natalizumab. Our data show that the frequency of the CD27(+)CD43(+) B1 cell subset was significantly diminished in RRMS patients compared to healthy subjects and that this subset was unaffected by treatment. Regardless of their true nature, we believe that these cells are part of the autoimmune disease pattern.

Keywords:
B cellsB1 cellsFlow cytometryMS

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