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Related Experiment Video

Updated: Apr 30, 2026

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Changes in whole-brain functional networks and memory performance in aging.

Roser Sala-Llonch1, Carme Junqué1, Eider M Arenaza-Urquijo2

  • 1Departament de Psiquiatria i Psicobiologia Clínica, Universitat de Barcelona, Barcelona, Catalonia, Spain; Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.

Neurobiology of Aging
|May 13, 2014
PubMed
Summary

Aging brains exhibit reduced long-range connectivity and increased local network segregation, impacting memory performance in older adults. This shift suggests a localized information processing pattern with age.

Keywords:
AgingFrontal lobeGraph theoryMemoryResting-state fMRI

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Area of Science:

  • Neuroscience
  • Cognitive Aging
  • Brain Connectivity

Background:

  • Aging is associated with changes in brain structure and function.
  • Understanding age-related alterations in functional brain connectivity is crucial for cognitive health.
  • Previous research suggests a link between brain network organization and cognitive decline.

Purpose of the Study:

  • To investigate how aging affects local and global functional brain connectivity.
  • To examine the relationship between age-related connectivity changes and memory performance.
  • To explore the impact of aging on brain network integration and segregation.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) data from 98 healthy older adults.
  • Whole-brain network construction via parcellation into 90 cerebral regions and pairwise connectivity analysis.
  • Graph theory metrics (minimum path length, clustering coefficients) to assess functional integration and segregation.

Main Results:

  • Aging correlated with decreased long-range connectivity in fronto-parietal and fronto-occipital systems.
  • Aging correlated with increased short-range connectivity within frontal, parietal, and occipital lobes.
  • Older adults exhibited less integrated and more segregated global networks, with higher clustering coefficients linked to poorer memory function.

Conclusions:

  • Older adults demonstrate reduced long-range functional brain connectivity and increased functional segregation.
  • These findings suggest a shift towards more localized information processing in aging brains.
  • Increased local clustering in older individuals is negatively associated with verbal and visual memory performance.