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Inflammatory breast cancer: a single centre analysis.

Ajay Gogia¹, Vinod Raina, Suryanarayan Vishnu Deo

¹Medical Oncology Department, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India

Asian Pacific Journal of Cancer Prevention : APJCP

|May 13, 2014

Summary

Inflammatory breast cancer (IBC) is a rare, aggressive breast cancer. This study in India found IBC accounts for 1.1% of cases, with many presenting at advanced stages and showing high rates of hormone and HER2/neu receptor positivity.

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Area of Science:

Oncology
Clinical Medicine
Cancer Research

Background:

Inflammatory breast cancer (IBC) is a rare, aggressive subtype of locally advanced breast cancer.
Characterized by rapid onset of erythema, edema, and peau d'orange, IBC presents unique diagnostic and therapeutic challenges.
Data on IBC in India are limited, necessitating local studies to understand its epidemiology and outcomes.

Purpose of the Study:

To evaluate the clinical-pathological characteristics of Inflammatory Breast Cancer (IBC) patients.
To determine the treatment outcomes for IBC at a major tertiary care center in India.
To provide data on the incidence and presentation of IBC within the Indian population.

Main Methods:

A retrospective review of 3,650 breast cancer cases registered between January 2004 and December 2012 was conducted.
41 cases of IBC were identified and analyzed for demographic, clinical, radiological, and histopathological data.
Exclusion criteria included recurrent IBC or advanced breast cancer mimicking IBC.

Main Results:

IBC represented 1.1% of all breast cancer cases at the center, with a median patient age of 45 years.
A significant proportion (one-third) of patients presented with metastatic disease (AJCC Stage IV).
Receptor status revealed 50% Estrogen Receptor (ER) positivity, 46% Progesterone Receptor (PR) positivity, and 60% HER2/neu positivity, with 15% triple-negative cases.

Conclusions:

Inflammatory Breast Cancer (IBC) is a distinct entity with specific clinical-pathological features observed in the Indian population.
High rates of hormone receptor and HER2/neu positivity were noted, influencing treatment strategies.
The study highlights the need for increased awareness and tailored management approaches for IBC in India, given its aggressive nature and presentation at advanced stages.