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Plasma procurement world-wide.

J Leikola1

  • 1Finnish Red Cross Blood Transfusion Service, Helsinki, Finland.

Beitrage Zur Infusionstherapie = Contributions to Infusion Therapy
|January 1, 1989
PubMed
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Globally, 75 million blood units are collected yearly, yielding 14 million liters of plasma. However, only 6 million liters are processed, with an additional 8 million liters sourced via plasmapheresis for fractionation.

Area of Science:

  • Blood collection and plasma fractionation
  • Global health and biopharmaceutical manufacturing

Background:

  • Annual global whole blood collection exceeds 75 million units, primarily in Europe, the Americas, and Western Pacific.
  • Potential plasma yield from whole blood is approximately 14 million liters, but current processing is significantly lower.

Purpose of the Study:

  • To analyze the global supply chain of blood plasma for fractionation.
  • To identify the sources and processing volumes of plasma for therapeutic protein production.

Main Methods:

  • Analysis of global blood collection statistics.
  • Quantification of plasma derived from whole blood and plasmapheresis.
  • Assessment of plasma fractionation capacities and geographical distribution.

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Main Results:

  • Approximately 6 million liters of plasma from whole blood are processed, supplemented by 8 million liters from plasmapheresis.
  • Over 60% of source plasma originates from paid donors in the U.S.
  • Plasma fractionation is dominated by commercial companies (70%) and concentrated in Europe (42%) and North America (47%).

Conclusions:

  • Significant underutilization of available plasma resources for fractionation exists globally.
  • The plasma supply chain relies heavily on paid donors and commercial fractionation entities.
  • Geographical concentration of fractionation activities in Europe and North America highlights potential supply chain vulnerabilities.