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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: Apr 30, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Update on primary mucosal melanoma.

Joselin D Tacastacas¹, Julie Bray², Yoon K Cohen¹

¹Department of Dermatology, University Hospitals Case Medical Center, Cleveland, Ohio.

Journal of the American Academy of Dermatology

|May 13, 2014

Summary

This summary is machine-generated.

Mucosal melanomas are aggressive cancers distinct from skin melanomas. Targeted therapies for C-KIT mutations show promise for treating these challenging mucosal tumors.

Keywords:

C-KIT inhibitors anorectal mucosal melanoma clinical characteristics mucosal melanoma of the head and neck pathology treatment urinary tract melanoma vulvar and vaginal mucosal melanoma

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Area of Science:

Oncology
Cancer Research
Melanoma Studies

Background:

Mucosal melanomas exhibit distinct clinical and pathological features compared to cutaneous melanomas.
Current treatment strategies, including surgery, lymph node management, and radiation therapy, require further clarification for mucosal melanoma.
Identifying specific molecular targets is crucial for developing effective therapies.

Purpose of the Study:

To highlight the unique characteristics of mucosal melanomas.
To discuss the established and uncertain aspects of current treatment modalities.
To emphasize the potential of targeted therapies for mucosal melanoma.

Main Methods:

Review of clinical and pathological data distinguishing mucosal from cutaneous melanomas.
Analysis of current surgical, lymph node, and radiation therapy practices.
Examination of emerging targeted therapies, particularly those addressing C-KIT mutations.

Main Results:

Mucosal melanomas possess unique features necessitating distinct staging and treatment approaches.
The efficacy of lymph node surgery and radiation therapy in mucosal melanoma remains undetermined.
Activating C-KIT mutations are prevalent in mucosal melanomas, indicating a potential therapeutic target.

Conclusions:

Mucosal melanomas require specialized management distinct from cutaneous melanomas.
Further research is needed to establish optimal lymph node surgery and radiation protocols.
Targeted therapies, especially for C-KIT mutations, represent a promising avenue for mucosal melanoma treatment.