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Updated: Apr 30, 2026
05:51
Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
Published on: May 3, 2018
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Wave reflections, arterial stiffness, and orthostatic hypotension
Shih-Hsien Sung, Zu-Yin Chen1, Tzu-Wei Tseng2
1Department of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Medicine, National Yang-Ming University Hospital, Yilan, Taiwan;
American Journal of Hypertension
|May 13, 2014
Summary
Wave reflections, measured by backward pressure wave amplitude (Pb), independently predict orthostatic hypotension (OH) and blood pressure changes during posture changes in adults.
Area of Science:
- Cardiovascular Physiology
- Hemodynamics
- Hypertension Research
Background:
- The impact of wave reflections on blood pressure during postural changes is not fully understood.
- Orthostatic hypotension (OH) is a significant clinical concern, particularly in older adults.
Purpose of the Study:
- To investigate the relationship between backward pressure wave amplitude (Pb) and orthostatic blood pressure changes.
- To determine if Pb predicts orthostatic hypotension (OH).
Main Methods:
- Analysis of hemodynamic data from 613 subjects, including brachial blood pressure, carotid-femoral pulse wave velocity (cf-PWV), and Pb.
- Measurement of blood pressure in supine and standing positions to assess orthostatic changes and define OH.
Main Results:
- Subjects with OH exhibited higher supine blood pressure and lower standing blood pressure, along with elevated cf-PWV and Pb.
- Both cf-PWV and Pb were independently associated with orthostatic SBP change and predicted OH.
- Pb showed consistent predictive value for OH across different age groups.
Conclusions:
- Wave reflections, quantified by Pb, are a significant independent factor influencing orthostatic blood pressure regulation.
- Backward pressure wave amplitude is a valuable predictor of orthostatic hypotension in both younger and older individuals.
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