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Rotation thromboelastometry and the hypercoagulable state in Cushing's syndrome
Maria Caroline Alves Coelho1, Leonardo Vieira Neto, Leandro Kasuki
1Department of Internal Medicine and Endocrine Unit, Medical School and Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Clinical Endocrinology
|May 13, 2014
Summary
Rotation thromboelastometry (ROTEM®) showed altered clot initiation in Cushing's syndrome (CS) patients, despite normal deep vein thrombosis screening. This study evaluates ROTEM® for hypercoagulability in CS.
Area of Science:
- Endocrinology
- Hematology
- Medical Diagnostics
Background:
- Cushing's syndrome (CS) is linked to hypercoagulability.
- Rotation thromboelastometry (ROTEM®) is a tool for assessing hypercoagulability.
- ROTEM® has not been previously evaluated in CS patients.
Purpose of the Study:
- To assess hypercoagulability in CS patients using ROTEM®.
- To correlate ROTEM® findings with standard coagulation markers.
- To investigate the association between ROTEM® parameters and deep vein thrombosis (DVT) in CS.
Main Methods:
- Thirty CS patients and 30 matched controls were enrolled.
- Coagulation markers including aPTT, platelets, fibrinogen, D-dimer, FVIII, vWF, and CRP were measured.
- ROTEM® analysis (INTEM, EXTEM, FIBTEM) and Doppler ultrasonography for DVT were performed.
Main Results:
- CS patients exhibited shorter INTEM clotting times and aPTT compared to controls.
- Elevated FVIII, vWF, and D-dimer levels were observed in CS patients.
- Obese CS patients showed specific ROTEM® alterations (INTEM MCF, alpha angle, speed; FIBTEM MCF); no DVTs were detected.
Conclusions:
- CS patients display altered clot initiation via ROTEM® and elevated FVIII/vWF levels.
- Despite hypercoagulability markers, no deep vein thrombosis was identified in the studied CS cohort.
- ROTEM® offers insights into coagulation dynamics in Cushing's syndrome.
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