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Small juxtacortical hemorrhages in cerebral venous thrombosis

Jonathan M Coutinho1, René van den Berg, Susanna M Zuurbier

  • 1Departments of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Annals of Neurology
|May 13, 2014
PubMed

Insights

Small juxtacortical hemorrhages (JCHs) are a characteristic sign of cerebral venous thrombosis (CVT). These hemorrhages are rare in other conditions, making them a key diagnostic indicator for CVT.

Area of Science:

  • Neurology
  • Radiology
  • Pathology

Background:

  • Intracerebral hemorrhages (ICHs) frequently occur in patients diagnosed with cerebral venous thrombosis (CVT).
  • The specific characteristics of these hemorrhages can aid in diagnosis.

Purpose of the Study:

  • To determine if small juxtacortical hemorrhages (JCHs) are a characteristic finding in CVT.
  • To investigate the radiological and pathological properties of JCHs in CVT patients.

Main Methods:

  • Retrospective analysis of patients with CVT and ICH between 2000-2011.
  • Defined JCH as a hemorrhage <20mm diameter in the subcortical white matter.
  • Compared JCH frequency in CVT patients versus a control group with non-CVT ICH.

Main Results:

  • JCHs were present in 26% of CVT patients with ICH (14/53).
  • Papilledema was more common in JCH patients (44% vs 9%).
  • JCHs were rare in the control group (3/196), with one reclassified as CVT.

Conclusions:

  • Small, nontraumatic JCHs are a characteristic feature of CVT.
  • JCHs are infrequently observed in other causes of ICH, suggesting diagnostic utility.
Abstract

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