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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Barrett Esophagus-I: Introduction01:21

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
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Esophageal Strictures-I: Introduction01:30

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Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
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Cancer Prevention02:59

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

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Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
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Related Experiment Video

Updated: Apr 30, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
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Epigenetics in esophageal cancers.

Theresa D Ahrens1, Martin Werner, Silke Lassmann

  • 1Department of Pathology, University Medical Center, Freiburg, Germany.

Cell and Tissue Research
|May 13, 2014
PubMed
Summary

This review updates knowledge on epigenetic alterations in esophageal cancers, focusing on microRNA, DNA methylation, and histone marks. These findings offer potential therapeutic targets for esophageal squamous cell carcinomas and Barrett

Area of Science:

  • Oncology
  • Gastroenterology
  • Epigenetics

Background:

  • Esophageal cancers, including squamous cell carcinomas and adenocarcinomas, are complex upper gastrointestinal tumors.
  • Genetic aberrations are known drivers of esophageal cancer development and progression.
  • Epigenetic alterations are increasingly recognized as significant factors in esophageal carcinogenesis.

Purpose of the Study:

  • To provide a critical update on the current knowledge of epigenetic alterations in esophageal cancers.
  • To focus on the translational aspects of epigenetic analyses from human tissue specimens.
  • To highlight potential novel therapeutic targets derived from epigenetic insights.

Main Methods:

  • Review of studies analyzing human esophageal cancer tissue specimens.

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  • Focus on analyses of microRNA (miRNA) expression patterns.
  • Examination of DNA methylation patterns and histone mark levels.

    • Main Results:

    • Altered patterns of miRNA expression are frequently observed in esophageal cancers.
    • Aberrant DNA methylation and histone modifications are characteristic epigenetic changes.
    • These epigenetic alterations correlate with carcinogenesis and progression.

    Conclusions:

    • Epigenetic alterations represent a crucial area of research in esophageal cancer.
    • Translational studies of epigenetic modifications in human tissues are vital.
    • Epigenetic findings offer promising avenues for novel therapeutic strategies.