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Updated: Apr 30, 2026
Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Versatile post-functionalization of the external shell of cowpea chlorotic mottle virus by using click chemistry
C A Hommersom1, B Matt, A van der Ham
1Laboratory for Biomolecular Nanotechnology, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands. n.h.katsonis@utwente.nl.
Abstract:
We present the modification of the outer protein shell of cowpea chlorotic mottle virus (CCMV) with linear and strained alkyne groups. These functionalized protein capsids constitute valuable platforms for post-functionalization via click chemistry. After modification, the integrity of the capsid and the reversible disassembly behavior are preserved.
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