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Updated: Apr 30, 2026
Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Protective effects of Jiashen Prescription () on myocardial infarction in rats
Ming-Jun Zhu1, You-Ping Wang, Shi-Yang Xie
1Division of Cardiology and Central Laboratory, First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, China, zhumingjun317@163.com.
Objective:
To evaluate the effects of Jiashen Prescription (, JSP) on myocardial infarction (MI) size and cardiac function at the early stage of MI in rats.
Methods:
One hundred male Sprague-Dawley rats were subjected to sham-operation or MI induced by ligating the left anterior descending coronary artery. The rats with MI were treated with vehicle, JSP 3 and 6 g/(kg·d), or losartan 10 mg/(kg·d) for 1 week.
Results:
Compared with the vehicle-treated MI rats, 6 g/(kg·d) JSP reduced MI size 3 days after MI (P<0.05), and attenuated the MI-induced increases in left ventricular end-diastolic and end-systolic dimension and decreases in fractional shortening and ejection fraction 1 week after MI (P<0.05). In addition, 6 g/(kg·d) JSP and losartan were equally effective in reducing MI size and enhancing cardiac functional recovery.
Conclusion:
JSP reduces MI size and improves cardiac function after MI, suggesting that JSP has potential as a therapy for MI.
