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Updated: Apr 30, 2026

Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay
Published on: April 5, 2019
[Joint swelling, reversible arm paresis, and elevated serum IgG4 in a 55-year-old man]
C Windisch1, H Merz, T Winkens
1Klinik für Innere Medizin III, Universitätsklinikum Jena, Erlanger Allee 101, 07740, Jena, Deutschland, christin.windisch@med.uni-jena.de.
Abstract:
Only described in the last 10 years, IgG4-related disease is a fibroinflammatory disorder characterized by tumorous lesions with dense lymphoplasmacytic infiltration by IgG4-positive plasma cells and often elevated concentration of serum IgG4. In this paper, we present a male patient with this disease involving the lymph nodes and possibly the joints and kidneys. Infiltration of lymph node tissue with IgG4-positive plasma cells was demonstrated. The general condition of the patient improved considerably by immunosuppressive therapy.
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