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Updated: Apr 30, 2026

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
Published on: November 11, 2018
Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes
Ashish Thapliyal1, Rashmi Verma1, Navin Kumar1
1Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand 248002, India.
Abstract:
Dexras1 and RHES, monomeric G proteins, are members of small GTPase family that are involved in modulation of pathophysiological processes. Dexras1 and RHES levels are modulated by hormones and Dexras1 expression undergoes circadian fluctuations. Both these GTPases are capable of modulating calcium ion channels which in turn can potentially modulate neurosecretion/hormonal release. These two GTPases have been reported to prevent the aberrant cell growth and induce apoptosis in cell lines. Present review focuses on role of these two monomeric GTPases and summarizes their role in pathophysiological processes.
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